UAB Department of Obstetrics and Gynecology
Division of Maternal and Fetal Medicine
Research Studies
NICHD Genomic and Proteomic Network for Preterm Birth Research
The Objective of this research network is to investigate genetic and environmental
factors for preterm birth using genomic and metabolomic approaches. The network is funded by the
National Institute of Child Health and Human Development (NICHD).
The ultimate goal of the Genomic and Proteomic Network for Preterm Birth Research,
refered to as GPN below, is to study the genetic and environmental etiologies and
mechanisms of spantaneous preterm birth (SPTB). Understanding those mechanisms will
help us predict SPTB, and design more effective prevention strategies for SPTB as well as
more effective treatment strategies for sequelae of preterm birth.
MFMU Network
A Randomized Trial of 17 Hydroxyprogesterone Caproate (17P)
for Prevention of Preterm Birth in Nulliparous Women with a Short Cervix. (SCAN)
The purpose of this trial is to determine whether treatment with progesterone (17P),
initiated after 16 weeks but before 23 weeks of gestation, reduces the risk of a
preterm delivery (before 37 weeks) in nulliparous women with a short cervix.
For
more information: (205) 934-1324
A Randomized Trial of Thyroxine Therapy for Subclinical Hypothyroidism
or Hypothyroxinemia Diagnosed During Pregnancy. (TSH)
This trial is being conducted to determine whether treating women, who are diagnosed with a mild imbalance
of thyroid hormones during pregnancy, with thyroid hormone replacement affects their
children's intellectual development at 5 years of age.
For
more information:(205) 934-1324
Combined Antioxidant and Preeclampsia Prediction Studies
A Randomized Clinical Trial of Antioxidants to Prevent Preeclampsia (CAPPS ACT)
The purpose of this study is to determine whether antioxidants (Vitamins C and E)
reduce the frequency of serious maternal and infant complications associated with
pregnancy-related high blood pressure (preeclampsia).
For more information: (205)
934-1324
Combined Antioxidant and Preeclampsia Prediction Studies
An Observational Cohort Study to Predict Preeclampsia (CAPPS)
The purpose of this study is to determine if changes in concentrations of biochemical
markers in blood and urine, and/or changes in biophysical markers (e.g., blood pressure,
weight, body fat) measured throughout gestation can predict the development
of preeclampsia (pregnancy-related high blood pressure).
For more information:(205) 934-1324
A Randomized Trial of Treatment for
Mild Gestational Diabetes Mellitus (GDM)
The purpose of this study is to see if diet therapy and blood sugar monitoring
will affect pregnancy outcomes, including reducing the risk of problems for newborns,
such as low blood sugar, jaundice, large babies and other pregnancy outcomes,
in pregnant women who have mild gestational diabetes.
For more information: (205) 934-1324